guo standard number: 61740
Chinese name: Acrylamide
English name: Acrylamide
Molecular formula: C3H5NO; CH2CHCONH2
Molecular weight: 71.08
Melting point: 84.5℃ Boiling point: 125℃/3
Density: relative density (water=1) 1.12;
Vapor pressure: 0.21kPa(84.5℃)
Solubility: soluble in water, ethanol, and, insoluble in benzene
Appearance and properties: white crystalline solid, odorless
Danger mark: 15 (poisonous)
Uses: Used to make water-soluble polymer, namely polyacrylamide
2. Impact on the environment:
1. Health hazards
Entry route: inhalation, ingestion, transdermal absorption.
Health hazards: This product has neurotoxic effects. It can cause fatigue, lethargy, numbness of the fingers, positional tremor, gait disturbance, muscle atrophy, muscle weakness, sweating and desquamation of hands, and contact dermatitis.
2. Toxicological information and environmental behavior
Toxicity: Moderately toxic.
Acute toxicity: LD50 150～180mg/kg (rat oral)
Sex: Rabbit eye: 5mg (24 o'clock), severe.
Subacute and chronic toxicity: Add 0.02%～0.04% of this product to the oral food of rats. After 1～6 months, there will be degeneration of peripheral nerves, axons and medullary membranes.
Mutagenicity: sister chromatid exchange: 600 mg/kg orally in rats for 10 days (continuous). Morphological changes: mice were injected intraperitoneally with 100 mg/kg.
Reproductive toxicity: Rat oral ZUI low toxic dose (TDL0): 200mg/kg (7 to 16 days gestation), causing biochemical and metabolic changes in newborn rats. Rat oral ZUI low toxic dose (TDL0): 544mg/kg (9 weeks, male), which caused changes in male fertility index and increased mortality after implantation.
Carcinogenicity: IARC carcinogenicity review: animal positive.
Hazardous characteristics: In case of high RE, open flame or contact with oxidants, there is a risk of burning. In case of high RE, polymerization reaction may occur and a large amount of RE will be released, causing container rupture and accidents.
Combustion (decomposition) products: carbon monoxide, carbon dioxide.
3. On-site emergency monitoring methods:
4. Laboratory monitoring methods:
Gas Chromatography "Water Quality Analysis Big Quan" Zhang Hongtao and other editors
Translation of guo environmental monitoring station, etc. in the "Manual of Solid Waste Test and Analysis Evaluation by Gas Chromatography"
Chromatography-mass spectrometry "Water and Wastewater Standard Inspection Method" 19th edition translation, Environmental Monitoring in Jiangsu Province
5. Environmental standards:
The former Soviet Union (1975) workshop hygiene standard 0.3mg/m3
Medium guo (to be promulgated) ZUI high allowable concentration of hazardous substances in drinking water source 0.0005mg/L
6. Emergency treatment methods:
1. Leakage emergency treatment
Isolate the leaking and contaminated area, and set up warning signs around it. It is recommended that emergency personnel wear anti-virus and chemical protective clothing. Do not directly touch the leakage, use a clean shovel to collect it in a dry and clean covered container, and transport it to a waste disposal site. It can also be washed with a large amount of water, and the diluted washing water is put into the waste water system. If there is a large amount of leakage, collect and recycle or discard after harmless treatment.
Waste disposal method: use incineration. The nitrogen oxides discharged from the incinerator are removed by scrubbers.
2. Protective measures
Respiratory protection: When the concentration in the air exceeds the standard, you should wear anti-virus. When QIANG rescues or escapes in an emergency, wear self-contained breathing apparatus.
Eye protection: Wear quan protective glasses when necessary.
Protective clothing: wear corresponding protective clothing.
Hand protection: Wear chemical-proof gloves.
Others: Smoking, eating and drinking are prohibited at the work site. After working, wash thoroughly. Store clothes contaminated by poisons separately and wash them before use. Perform pre- and regular physical examinations.
3. First aid measures
Skin contact: Take off contaminated clothing and rinse thoroughly with soap and water.
Eye contact: immediately lift the eyelids and rinse with running water.
Inhalation: Leave the scene to fresh air. Give artificial respiration if necessary. Seek medical attention.
Ingestion: If you take it by mistake, drink plenty of warm water to induce vomiting. Seek medical attention.
Extinguishing methods: carbon dioxide, dry powder, sandy soil.
Acrylamide molecular structure and computational chemistry data
Molecular structure data
1. Molar refractive index: 19.23
2. Molar volume (cm3/mol): 73.9
3. Isotonic specific volume (90.2K): 174.6
4. Surface tension (dyne/cm): 31.0
5. Polarizability (10-24cm3): 7.62
Computational chemistry data
1. Hydrophobic parameter calculation reference value (XlogP): -0.7
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 1
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: 2
6. Topological molecular polar surface area (TPSA): 43.1
7. Number of heavy atoms: 5
8. Surface charge: 0
9. Complexity: 57.9
10. Number of isotopic atoms: 0
11. Determine the number of xin in the atomic structure: 0
12. Uncertain the number of xin in the atomic structure: 0
13. Determine the number of xin in the chemical bond stereo: 0
14. Uncertain the number of xin in the chemical bond stereo: 0
15. Number of covalent bond units: 1
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