丙烯酰胺 毒理性

2020-09-29 21:42
 
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丙烯酰胺 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :AS3325000

CHEMICAL NAME :Acrylamide

CAS REGISTRY NUMBER :79-06-1

BEILSTEIN REFERENCE NO. :0605349

LAST UPDATED :199712

DATA ITEMS CITED :140

MOLECULAR FORMULA :C3-H5-N-O

MOLECULAR WEIGHT :71.09

WISWESSER LINE NOTATION :ZV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :Standard Draize test

ROUTE OF EXPOSURE :Administration onto the skin

SPECIES OBSERVED :Rodent - rabbit

TYPE OF TEST :Standard Draize test

ROUTE OF EXPOSURE :Administration onto the skin

SPECIES OBSERVED :Rodent - rabbit

TYPE OF TEST :Rinsed with water

ROUTE OF EXPOSURE :Administration into the eye

SPECIES OBSERVED :Rodent - rabbit

TYPE OF TEST :Standard Draize test

ROUTE OF EXPOSURE :Administration into the eye

SPECIES OBSERVED :Rodent - rabbit

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :124 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Administration onto the skin

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :400 mg/kg

TOXIC EFFECTS :Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - peptidases

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :90 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Unreported

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :208 mg/kg

TOXIC EFFECTS :Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :107 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :170 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Unreported

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :156 mg/kg

TOXIC EFFECTS :Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :150 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Administration onto the skin

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :1680 uL/kg

TOXIC EFFECTS :Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Unreported

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :280 mg/kg

TOXIC EFFECTS :Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :150 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :170 mg/kg

TOXIC EFFECTS :Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Unreported

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :173 mg/kg

TOXIC EFFECTS :Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Bird - quail

DOSE/DURATION :186 mg/kg

TOXIC EFFECTS :Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Mammal - species unspecified

DOSE/DURATION :100 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Mammal - species unspecified

DOSE/DURATION :190 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1035 mg/kg/15W-I

TOXIC EFFECTS :Behavioral - muscle weakness Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :608 mg/kg/16D-C

TOXIC EFFECTS :Spinal Cord - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1800 mg/kg/90D-C

TOXIC EFFECTS :Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :600 mg/kg/6W-C

TOXIC EFFECTS :Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :286 mg/kg/28D-C

TOXIC EFFECTS :Brain and Coverings - changes in brain weight Cardiac - changes in heart weight Blood - pigmented or nucleated red blood cells

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :108 mg/kg/3W-I

TOXIC EFFECTS :Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :168 mg/kg/2W-C

TOXIC EFFECTS :Behavioral - muscle weakness

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :780 mg/kg/13W-I

TOXIC EFFECTS :Spinal Cord - demyelination Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - ataxia

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :400 mg/kg/8D-I

TOXIC EFFECTS :Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1155 mg/kg/13W-I

TOXIC EFFECTS :Peripheral Nerve and Sensation - sensory change involving peripheral nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1 gm/kg/8W-I

TOXIC EFFECTS :Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Peripheral Nerve and Sensation - structural change in nerve or sheath

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :568 mg/kg/8W-I

TOXIC EFFECTS :Related to Chronic Data - changes in testicular weight

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :1200 mg/kg/4W-I

TOXIC EFFECTS :Behavioral - muscle weakness Related to Chronic Data - death

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Mammal - dog

DOSE/DURATION :330 mg/kg/22D-I

TOXIC EFFECTS :Peripheral Nerve and Sensation - recording from peripheral motor nerve Behavioral - muscle weakness Behavioral - ataxia

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Primate - monkey

DOSE/DURATION :671 mg/kg/75W-I

TOXIC EFFECTS :Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - changes in motor activity (specific assay) Related to Chronic Data - death

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Primate - monkey

DOSE/DURATION :450 mg/kg/61D-I

TOXIC EFFECTS :Peripheral Nerve and Sensation - sensory change involving peripheral nerve

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Primate - monkey

DOSE/DURATION :200 mg/kg/2D-I

TOXIC EFFECTS :Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Primate - monkey

DOSE/DURATION :200 mg/kg/4D-I

TOXIC EFFECTS :Related to Chronic Data - death

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Mammal - cat

DOSE/DURATION :771 mg/kg/1Y-I

TOXIC EFFECTS :Behavioral - muscle weakness

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Mammal - cat

DOSE/DURATION :150 mg/kg/10D-I

TOXIC EFFECTS :Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intramuscular

SPECIES OBSERVED :Mammal - cat

DOSE/DURATION :300 mg/kg/10D-I

TOXIC EFFECTS :Spinal Cord - other degenerative changes Behavioral - muscle weakness

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Bird - chicken

DOSE/DURATION :450 mg/kg/3W-I

TOXIC EFFECTS :Behavioral - muscle weakness Behavioral - ataxia

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1456 mg/kg/2Y-C

TOXIC EFFECTS :Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - testicular tumors

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :24 mg/kg/8W-I

TOXIC EFFECTS :Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :300 mg/kg/2W-I

TOXIC EFFECTS :Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :72 mg/kg/8W-I

TOXIC EFFECTS :Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1456 mg/kg/2Y-C

TOXIC EFFECTS :Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :200 mg/kg

SEX/DURATION :female 7-16 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :560 mg/kg

SEX/DURATION :female 6-21 day(s) after conception lactating female 10 day(s) post-birth

TOXIC EFFECTS :Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :75 mg/kg

SEX/DURATION :male 5 day(s) pre-mating

TOXIC EFFECTS :Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :140 mg/kg

SEX/DURATION :female 2 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :150 mg/kg

SEX/DURATION :male 5 day(s) pre-mating

TOXIC EFFECTS :Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :350 mg/kg

SEX/DURATION :male 7 day(s) pre-mating

TOXIC EFFECTS :Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :400 mg/kg

SEX/DURATION :male 8 day(s) pre-mating

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :571 mg/kg

SEX/DURATION :male 16 day(s) pre-mating

TOXIC EFFECTS :Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :95 gm/kg

SEX/DURATION :male 4 week(s) pre-mating

TOXIC EFFECTS :Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :95 gm/kg

SEX/DURATION :female 4 week(s) pre-mating

TOXIC EFFECTS :Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :71 gm/kg

SEX/DURATION :male 4 week(s) pre-mating

TOXIC EFFECTS :Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :225 mg/kg

SEX/DURATION :female 10-12 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :125 mg/kg

SEX/DURATION :female 1 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :250 mg/kg

SEX/DURATION :male 5 day(s) pre-mating

TOXIC EFFECTS :Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :300 mg/kg

SEX/DURATION :female 8-10 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :75 mg/kg

SEX/DURATION :female 12 day(s) after conception

TOXIC EFFECTS :Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :225 mg/kg

SEX/DURATION :female 10-12 day(s) after conception

TOXIC EFFECTS :Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :Specific locus test

TYPE OF TEST :Micronucleus test

TYPE OF TEST :Unscheduled DNA synthesis

TYPE OF TEST :Sister chromatid exchange

TYPE OF TEST :Dominant lethal test

TYPE OF TEST :Micronucleus test

TYPE OF TEST :Specific locus test

TYPE OF TEST :DNA damage

TYPE OF TEST :Unscheduled DNA synthesis

TYPE OF TEST :Cytogenetic ysis

TYPE OF TEST :Cytogenetic ysis

TYPE OF TEST :Sister chromatid exchange

TYPE OF TEST :Sex chromosome loss and nondisjunction

TYPE OF TEST :Dominant lethal test

TYPE OF TEST :Dominant lethal test

TYPE OF TEST :Sperm Morphology

TYPE OF TEST :Sperm Morphology

TYPE OF TEST :Heritable translocation test

MUTATION DATA

TYPE OF TEST :Sex chromosome loss and nondisjunction

TEST SYSTEM :Rodent - hamster Lung

REFERENCE :MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 245,191,1990 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of al Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.03 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of al Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,41,1986 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,389,1994 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,41,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,389,1994 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,389,1994 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S.   Printing Office, Supt of Documents, Washington, DC 20402) ****- 1972- Volume(issue)/page/year: 11,129,1975 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,365,1973 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW CJNSA2 Canadian Journal of Neurological Sciences. (Faculty of Medicine, 2500 University Dr., Calgary, Alberta, Canada) V.1- 1974- Volume(issue)/page/year: 1,143,1974 TOXICOLOGY REVIEW CJNSA2 Canadian Journal of Neurological Sciences. (Faculty of Medicine, 2500 University Dr., Calgary, Alberta, Canada) V.1- 1974- Volume(issue)/page/year: 1,152,1974 TOXICOLOGY REVIEW NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 3,445,1981 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.3 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of al Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,5,1971 OSHA PEL (Gen Indu):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S.   Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S.   Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S.   Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S.   Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.3 mg/m3;S 0.9 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.3 mg/m3 JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:S 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 0.3 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.3 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.3 mg/m3;Skin JAN 1993 OEL-RUSSIA:S 0.2 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.3 mg/m3;S 0.9 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.3 mg/m3;S 0.6 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ACRYLAMIDE-air:10H CA TWA 0.03 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03540 No. of Facilities: 442 (estimated) No. of Industries: 10 No. of Occupations: 24 No. of Employees: 7047 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03540 No. of Facilities: 453 (estimated) No. of Industries: 19 No. of Occupations: 22 No. of Employees: 10651 (estimated) No. of Female Employees: 721 (estimated)



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