甲基丙烯酰胺毒理学数据：

Toxicological data: toxicology

Toxicological data:

1. Acute toxicity [15]

LD50: 150~180mg/kg (oral for rats)

2. Sex [16]

Rabbit percutaneous: 500mg (24h), mild.

Rabbit eye: 100mg (24h), moderate.

3. Subacute and chronic toxicity [17] Repeated poisonings for many times, almost quan animals have peripheral nerve damage, showing muscle weakness of the limbs, severe paralysis of the hind limbs, muscle atrophy of the distal limbs, sensory impairment and loss of tendon reflexes.

4. Sensitization [18] It has a sensitizing effect on the skin.

Mutagenicity Sister chromatid exchange: 600 mg/kg orally in rats (continuous 10 days). Morphological changes: mice were injected intraperitoneally with 100 mg/kg.

5. Teratogenicity [19] Female mice are exposed to 540mg/kg orally at 6-17 days after conception, which can cause malformations of the musculoskeletal system of the offspring.

6. Carcinogenicity [20] IARC carcinogenicity review: G2A, a possible human carcinogen.

7. Others [21] Oral ZUI low toxic dose (TDLo) in rats: 200mg/kg (7~16d of pregnancy), causing biochemical and metabolic changes in newborn rats. Oral ZUI low toxic dose (TDLo) in rats: 544mg/kg (9 weeks, male), which caused changes in male fertility index and increased mortality after implantation.

Ecological data:

1. Ecotoxicity[22]

LC50: 103~115mg/L (96h) (blackhead fish); 110mg/L (96h) (rainbow trout); 100mg/L (96h) (blue gill sunfish); 160mg/L (48h) (water fleas)

2. Biodegradability No data available

3. Non-biodegradability [23] In the air, when the concentration of hydroxyl groups is 5.00×105/cm3, the degradation half-life is 1.4d (theoretical).

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